Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
نویسندگان
چکیده
منابع مشابه
Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.
Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T cell function are related to the level of CD45 expression but not to which CD45 isoform is expre...
متن کاملDisruption of Lymphocyte Function and Signaling in CD45–associated Protein–null Mice
CD45-AP specifically associates with CD45, a protein tyrosine phosphatase essential for lymphocyte differentiation and antigen receptor-mediated signal transduction. CD45 is thought to mediate antigen receptor signaling by dephosphorylating regulatory tyrosine residues on Src family protein tyrosine kinases such as Lck. However, the mechanism for regulating CD45 protein tyrosine phosphatase act...
متن کاملA high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.
CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative splicing in the extracellular domain, and different patterns of CD45 splicing are associated with distinct functions. Lack of CD45 leads to severe combined immunodeficiency, and alterations of CD45 splici...
متن کاملCombinations of CD45 isoforms are crucial for immune function and disease.
Expression of the CD45 Ag in hemopoietic cells is essential for normal development and function of lymphocytes, and both mice and humans lacking expression exhibit SCID. Human genetic variants of CD45, the exon 4 C77G and exon 6 A138G alleles, which alter the pattern of CD45 isoform expression, are associated with autoimmune and infectious diseases. We constructed transgenic mice expressing eit...
متن کاملCD45-associated protein inhibits CD45 dimerization and upregulates its protein tyrosine phosphatase activity Running head: CD45-AP INHIBITS CD45 DIMERIZATION
CD45, a receptor-like protein tyrosine phosphatase (PTP), plays an essential role in lymphocyte development and immune responses. Recent evidence suggests that dimerization of CD45 downregulates its function. However, the mechanisms by which CD45 dimerization is regulated remain unclear and there is no direct evidence that the PTP activity of CD45 dimers is less than that of monomers. CD45 in l...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2004
ISSN: 1460-2377
DOI: 10.1093/intimm/dxh135